Matrix GLA Protein, a Regulatory Protein for Bone Morphogenetic Protein-2
نویسندگان
چکیده
منابع مشابه
Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
RATIONALE Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4. OBJECTIVE The objective was to determine whether MGP also binds other proteins, which could interfere with its function. METHODS AND RESULTS We transfected bovine aortic endothelial cells with N-terminally FLAG-tagged MGP and used immunoprecipitation and liqui...
متن کاملEvaluation of gene expression pattern of matrix gla protein and Bone gla protein as skeletogenesis markers in Persian sturgeon (Acipenser persicus Bordin, 1897)
Bone gla protein and matrix gla protein are of common origin with evolutionary relation and have similar structural features and are functional in the formation of skeletal structures The present study have been evaluated the genes encoding vitamin k-dependant proteins (VKDPs) expression at hatching time (0), 1, 3, 6, 10, 12,14, 20, 30 and 50 in skeletal Persian sturgeon sturgeon (Acipenser per...
متن کاملInhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency
OBJECTIVE Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and mesenchymal transition of endothelial cells (EndMT). In this study, we investigated the contribution...
متن کاملاثر اسیدهای چرب جیره ای بر رشد فولیکولی و میزان بیان ژن bone morphogenetic protein 15 در گوسفند
چکیده اسیدهای چرب غیراشباع با چندین پیوند دوگانه می توانند در روندهای تولید مثلی مختلف از طریق سازوکارهای متنوعی تاثیر بگذارند. در این مطالعه تاثیرات مکمل های اسیدهای چرب امگا 3 و امگا 6 بر ویژگی های تکامل فولیکولی و استروئیدزایی تخمدان و همچنین بیان فاکتور رشد bone morphogenetic protein 15 در اووسیت، که در فولیکول زایی تخمدانی نقش دارد، بررسی شد. 30 میش 4-2 ساله-ی غیرشیرده به 3 گروه 10 تایی ت...
15 صفحه اولCartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
RATIONALE Vascular calcification is a significant contributor to cardiovascular morbidity and mortality. We recently reported that cartilage oligomeric matrix protein (COMP) is pivotal for maintaining the homeostasis of vascular smooth muscle cells (VSMCs). Whether COMP affects the process of vascular calcification is unknown. OBJECTIVE We aimed to test whether COMP modulates vascular calcifi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m109683200